Job Description

At Horizon Therapeutics, we define success by the number of lives touched, lives changed, and lives saved. Our global biotechnology company is made up of agile, out-of-the-box thinkers with a focus on delivering breakthrough medicines to those living with rare, autoimmune, and severe inflammatory diseases. This is the heart of our global mission. Start a career that enables you to live up to your potential and help others live up to theirs. Join us.

The exceptional support we provide patients and communities equally extends to our employees. We offer industry-leading and award-winning benefits, compensation and rewards programs that positively impact all areas of our employees\' personal and professional lives.

Position Summary

Horizon is currently seeking a protein engineer to support pre-clinical program development in autoimmunity, inflammation, and rare diseases. This person will be responsible for leading protein engineering efforts for multiple large-molecule pre-clinical programs. This person will be expected to engage in the discovery and molecular engineering of biotherapeutics (antibodies, enzymes, fusion proteins etc.) as well as develop new processes and technologies for therapeutic discovery.

Responsibilities

• The ideal candidate will have broad laboratory training background, a deep understanding of large-molecule therapeutic pre-clinical development, scientific curiosity and a positive approach to working in a team-based research environment along with a track record of creative problem-solving, taking on difficult research challenges and delivering results.
• You will leverage your strong leadership skills to implement bold new ideas and manage stakeholders within and outside of Horizon\'s research team.
• As an Associate Director within the protein engineering group, you will provide leadership, mentorship, training, and technical expertise to a multi-disciplinary group of scientists.

• Innovate new methods, technologies, or make recommendations for onboarding existing ones, to continually improve the quality and speed of discovery of biologics for therapeutic applications
• Analyze, interpret, document and present data to the scientific and leadership teams.
• Work with stakeholders in various therapy areas to validate innovations by executing live discovery programs that show benefit to therapeutic discovery
• Design and conduct experiments within the lab, as needed, to further support your team
• Provide analysis, interpretation, troubleshooting and next steps on experimental workflows
• Manage work via CROs or external stakeholders/partners/collaborators

Qualifications and Skills Required

• Ph.D in a biological discipline focused on enzyme engineering, protein biochemistry, directed evolution, and protein design or a related field.
• 8+ years of industry experience and deep expertise with antibody and/or enzyme engineering, computational design, enzyme evolution and molecular biology technologies, high throughput screening, display technologies. Post-doctoral work may serve as experience.
• Proven track record of managing, executing, and delivering successful protein engineering projects in an industry environment.
• Deep understanding of human immunology and the ability to communicate and work with disease area experts on advancing pre-clinical programs is required
• Expertise in protein structure modeling and analysis (e.g. Schrodinger, MOE, pyMol, etc.) is desirable.
• Experience with bispecific/multispecific antibody technology as well as design, expression, purification, and biochemical characterization of various antibody formats is highly desirable.
• Experience with the following instruments or techniques is highly desirable: imaging/multicolor flow cytometry-based instruments, HTP-based binding assays (such as ELISA, SPR, BLI, MSD), cell-based assays (Intellicyt), affinity chromatography, ion-exchange chromatography.
• Strong publication record
• Outstanding communication and presentation skills
• Excellent organizational and record keeping skills
• People management/training experience is desirable

Our Values

• Transparency: We value collaboration. Trusting teach other and tackling tough challenges can make a powerful difference.
• Accountability: We do what\'s right for our patient communities through quality decisions and owning our successes and failures.
• Growth: We fiercely innovate and evolve to better ourselves, our communities and our patients.

These three values come to life through our five Leadership Expectations that apply to all Horizon employees

• Enterprise Mindset: Look beyond one\'s team, brand or function to see the broader company and external perspective
• Exhibit Intellectual Curiosity: Seek to understand what you do not know; ask the right questions of the right people and sources
• Ensure Accountability and Courage: Step up to address difficult issues and hold self and others accountable to commitments
• Embrace Diverse Perspectives: Welcome others with a respectful attitude; integrate diverse perspectives into ways of working
• Develop Talent: Provide feedback, coaching and mentorship to help others be more effective in their role

At Horizon, we know that disease does not discriminate. We embrace the bold ideas of one another, foster a sense of belonging, and value inclusion. We attract and develop diverse talent because we believe that when people from different backgrounds and life experiences come together, we make lives better.

Horizon intends that all qualified applications are given equal opportunity, and that selection decisions be based on job-related factors. We do not discriminate based on race, color, religion, gender, sexual orientation, national origin, age, disability, veteran status, or any other characteristics protected by law.

Horizon Therapeutics