Job Description

POSITION OBJECTIVE

Working under moderate supervision, perform research work in medical and related technical biomedical engineering. The research position will be focused on in vitro and in vivo studies of hemostatic nanoparticles that can treat bleeding dysfunctions. Specifically, these studies will include biochemical assays, viscoelastometric assays, microfluidic assays of bleeding dysfunction and rescue in vitro, and small animal models of bleeding injury (and its treatment) in vivo. The research is supported by US Department of Defense. The position supports translational research and technology development in the biomedical area, focused on a critical and clinical pathological problem of bleeding, and grows the education and research mission of Case Western Reserve University at department, school, and university levels. This position will work with animals.

ESSENTIAL FUNCTIONS * Perform studies using blood analysis instruments and laboratory assays (biochemical assays, viscoelastometric assays, microfluidic assays of bleeding dysfunction and rescue in vitro). The assays include but not limited to fluorescence microscopy assisted microfluidic experiments for analysis of blood clot formation and clot dissolution, rotational thromboelastometry and thromboelastography assisted viscoelastometric analysis of blood clots, UV-Visible spectrophotometry assisted analysis of thrombin and fibrin generation relevant to blood clot formation, high resolution microscopy of platelets, RBCs and fibrin associated with clot morphology. (30%)

• Perform studies of animal preclinical models of bleeding and clotting, to test hemorrhage control technologies developed in the laboratory. The preclinical models include mouse models of tail-clip bleeding and rat models of liver hemorrhage, where the animals are treated with bleeding mitigation therapeutic technologies developed in the laboratory, and reduction of bleeding is monitored along with recording animal vitals of blood pressure, oxygen saturation and temperature. (20%)
• Perform analysis of blood and plasma samples. Human blood will be obtained from the biorepository core of Case Western Reserve University and processed (e.g. centrifugation, dilution, drug treatment etc.) in vitro to simulate disease-associated conditions, and then treatment of such conditions with technologies developed in the laboratory, will be tested in vitro using methods described in #1 above. (20%)
• Maintain study results and records from microfluidic studies with blood samples and nanoparticles, and other experiments, and present research data at lab meetings and conferences. (10%)
• Maintain Bioflux microfluidic systems, fluorescence microscope test equipment and other equipment utilized in experiments. (10%)
• Order laboratory supplies (ex: tissue plasminogen activator human). (8%)

NONESSENTIAL FUNCTIONS

Perform other duties as assigned. (2%)

CONTACTS

Department: Daily contact with supervisor to discuss research and maintain workflow.

University: Occasional contact with other departments to share information.

External: Limited or no contact with vendors to exchange information.

Students: Contact with student employees to exchange information.

SUPERVISORY RESPONSIBILITY

This position has no direct supervision of staff employees.

QUALIFICATIONS

Education/Experience: Bachelor\xe2\x80\x99s degree in science and 0 to 1 year of experience or Associate\'s degree in an approved biotechnology program and 0 to 2 years of experience required.

REQUIRED SKILLS * Has knowledge of commonly-used concepts, practices, and procedures within the field of hematology, hemostasis, thrombosis and other bleeding dysfunctions.

• Relies on instructions and pre-established guidelines to perform the functions of the job.
• Ability to operate laboratory equipment. Typical equipment include fluorescence microscopy, microfluidic systems, UV-Visible spectrometry, nanoparticle manufacturing devices, dynamic light scattering devices, high resolution confocal microscopy.
• Ability to meet consistent attendance.
• Ability to interact with colleagues, supervisors and customers face to face.
• Must demonstrate compliance with university animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
• Must demonstrate compassion for animals within university facilities and dedication to the Animal Resource Center\xe2\x80\x99s mission. Must handle animals with care and respect at all times.
• Must be able and willing to learn new techniques, procedures, processes, and computer gear to protect the health of the animals.
• Must be able and willing to maintain a high standard of personal cleanliness and utilize protective gear to protect the health the animals.
• Previous experience working with animals preferred.

WORKING CONDITIONS

General laboratory environment. The employee will be exposed to wet chemistry, microfluidics, human blood and plasma samples, in vivo small animal studies.

Case Western Reserve University\'s animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals\xe2\x80\x9d appropriate Federal Animal Welfare Regulations, and the Public Health Service \xe2\x80\x9cPolicy on the Humane Care and Use of Laboratory Animals." This position, and all animal research personnel, are subject to internal compliance to medical school Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.

Term Position

This is a Term position. They are treated like regular staff positions for medical and dental benefits eligibility, vacation, holidays, and sick time. Term employees are not eligible for life insurance, retirement, long term disability, short term disability, tuition assistance, layoff status, or severance pay. Staff in term positions are also subject to the performance management review process and positive corrective action when work performance or behavior is unsatisfactory or unacceptable. Term employment does not alter the employment-at-will employee status of these employees.

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Diversity Statement

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

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Reasonable Accommodations

Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

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Case Western Reserve University