Job Description

Senior Scientist - Off-Target Characterization and Genomics

Direct Hire Fulltime Role

Salary Range: $140,000 - $170,000 per year

Location: South San Francisco, CA - Onsite Role

Description:

As a Senior Scientist, you will enable the characterization and quantitation of unintended off-target genome editing with CRISPR using high throughput next-generation sequencing (NGS) and other methodologies. You will work on various genetic disease areas across different stages of therapeutic development.

Roles and responsibilities:

• Conceptualize, thoroughly plan, and present study project plans with little oversight.
• Evaluate, develop, and execute genome-wide off-target characterization experiments to support guide characterization for therapeutic development
• Efficiently use Amplicon-seq, RNA-seq, Whole Exome-seq, Whole Genome-seq, Genome-wide seq, Translocation-seq, ChIP-Seq, and genome-wide methylation assay for off-target characterization and other studies
• Apply extensive scientific knowledge and broad laboratory skills to execute complex bench experiments using a variety of molecular biology, cell biology, and general laboratory techniques.
• Troubleshoot and optimize, both independently and in collaboration, with colleagues
• Accurately document project and sample information, protocols, and experimental details
• Collaborate with Quality Control and Quality Assurance teams to generate technical study reports supporting regulatory filings (IND or CTA equivalent)
• Participate in regulatory interaction meetings, responses to questions from regulators, and strategic communication of off-target characterization results.
• Interact with and assist other team members as needed to meet research objectives.
• Oversees activities and assists with training more junior research personnel.

Qualifications:

• Ph.D. degree (in Biology, Genetics, or a related life sciences field), 3+ years of NGS technologies and workflows experience in the industry
• Produce demonstration datasets and execute primary analysis for collaborations.
• Participate in preparing marketing collateral to support product launches, including peer-reviewed publications, application notes, protocols, webinars, and posters.
• Experience with DNA analysis/genomics applications in NGS, qPCR, or CRISPR is required.
• Previous experience with publishing scientific papers in peer-reviewed journals is preferred.
• Previous experience with regulatory agencies (FDA, OTAT, etc.) or regulatory filing preferred.
• Excellent organizational skills, ability to multi-task and work cross-functionally
• Strong organizational skills and attention to detail.

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